THE JOURNAL OF ANTIBIOTICS FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCEDBY Chromobacterium violaceum No. 968 I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES, AND ANTITUMOR ACTIVITY
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چکیده
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacteriumviolaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and humantumor cell lines both in vitro and in vivo. 301
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